Cov kab mob neurodegenerative(NDDs) yog tus cwj pwm los ntawm kev loj hlob lossis tsis tu ncua ntawm cov neeg tsis muaj zog neuronal hauv lub hlwb lossis qaum qaum. Kev faib tawm ntawm NDDs tuaj yeem ua raws li ntau yam qauv, suav nrog kev faib tawm anatomical ntawm neurodegeneration (xws li cov kab mob extrapyramidal, frontotemporal degeneration, los yog spinocerebellar ataaxias), thawj qhov txawv txav ntawm lub cev (xws li amyloid-β, prions, tau, lossis α-synuclein), los yog cov kab mob loj hauv cov kab mob trophic, cov tsos mob ntawm cov kab mob trophic ntawm cov kab mob hauv lub cev. sclerosis, thiab dementia). Txawm hais tias qhov sib txawv no hauv kev faib tawm thiab cov tsos mob tshwm sim, cov kab mob xws li Parkinson's Disease (PD), Amyotrophic Lateral Sclerosis (ALS), thiab Alzheimer's Disease (AD) qhia txog cov txheej txheem hauv qab uas ua rau muaj kev ua haujlwm tsis zoo hauv hlwb thiab kev tuag ntawm tes.
Nrog ntau lab tus neeg thoob ntiaj teb cuam tshuam los ntawm NDDs, Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb tau kwv yees tias los ntawm 2040, cov kab mob no yuav dhau los ua qhov thib ob ua rau tuag hauv cov tebchaws tsim kho. Txawm hais tias muaj ntau yam kev kho mob muaj los txo thiab tswj cov tsos mob cuam tshuam nrog cov kab mob tshwj xeeb, txoj hauv kev zoo los ua kom qeeb lossis kho qhov kev loj hlob ntawm cov xwm txheej no tseem tsis pom. Cov kev tshawb fawb tsis ntev los no qhia txog kev hloov pauv hauv kev kho mob los ntawm kev tswj cov tsos mob tsuas yog siv cov txheej txheem tiv thaiv ntawm tes los tiv thaiv kev puas tsuaj ntxiv. Cov pov thawj dav dav qhia tias oxidative kev nyuaj siab thiab mob ua rau lub luag haujlwm tseem ceeb hauv neurodegeneration, tso cov txheej txheem no ua lub hom phiaj tseem ceeb rau kev tiv thaiv cellular. Nyob rau hauv xyoo tas los no, kev tshawb fawb hauv paus thiab chaw kho mob tau nthuav tawm lub peev xwm ntawm Hyperbaric Oxygen Therapy (HBOT) hauv kev kho cov kab mob neurodegenerative.
Nkag siab Hyperbaric Oxygen Therapy (HBOT)
HBOT feem ntau suav nrog kev nce siab mus rau saum toj 1 qhov chaw tsis zoo (ATA) - qhov siab ntawm hiav txwv theem - rau lub sijhawm ntawm 90-120 feeb, feem ntau xav tau ntau qhov kev sib tham nyob ntawm seb qhov xwm txheej twg raug kho. Cov huab cua ua kom zoo dua tuaj yeem txhim kho kev xa tawm ntawm cov pa oxygen mus rau cov hlwb, uas ua rau cov kab mob cell proliferation thiab txhim kho cov txheej txheem kho kom zoo los ntawm qee yam kev loj hlob.
Keeb kwm, daim ntawv thov ntawm HBOT tau tsim los ntawm Boyle-Marriott txoj cai, uas tso cai rau kev txo qis ntawm cov pa npuas, nrog rau cov txiaj ntsig ntawm cov pa oxygen siab hauv cov ntaub so ntswg. Muaj ntau yam pathologies paub tias tau txais txiaj ntsig los ntawm lub xeev hyperoxic uas tsim los ntawm HBOT, suav nrog cov ntaub so ntswg necrotic, raug mob hluav taws xob, kev raug mob, kub hnyiab, kev sib koom ua ke, thiab gas gangrene, nrog rau lwm cov npe los ntawm Undersea thiab Hyperbaric Medical Society. Qhov tseem ceeb, HBOT kuj tau pom tias muaj txiaj ntsig zoo li kev kho mob ntxiv rau hauv ntau yam kab mob los yog kab mob sib kis, xws li colitis thiab sepsis. Muab nws cov tshuaj tiv thaiv kab mob thiab oxidative mechanisms, HBOT muaj peev xwm tseem ceeb raws li txoj kev kho mob rau cov kab mob neurodegenerative.
Preclinical Studies of Hyperbaric Oxygen Therapy in Neurodegenerative Diseases: Kev Pom Zoo los ntawm 3 × Tg Mouse Model
Ib qho ntawm cov kev tshawb fawb tseem ceebtsom mus rau 3 × Tg nas qauv ntawm Alzheimer's disease (AD), uas qhia txog kev kho lub peev xwm ntawm HBOT hauv ameliorating kev txawj ntse tsis txaus. Kev tshawb fawb koom nrog 17-hli-laus txiv neej 3 × Tg nas piv rau 14-hli-laus txiv neej C57BL / 6 nas ua haujlwm. Txoj kev tshawb no pom tau hais tias HBOT tsis tsuas yog txhim kho kev txawj ntse tab sis kuj txo qis qhov mob, cov quav hniav, thiab Tau phosphorylation - cov txheej txheem tseem ceeb cuam tshuam nrog AD pathology.
Cov teebmeem tiv thaiv ntawm HBOT tau raug ntaus nqi los ntawm kev txo qis hauv neuroinflamation. Qhov no tau ua pov thawj los ntawm kev txo qis ntawm microglial proliferation, astrogliosis, thiab tso tawm ntawm pro-inflammatory cytokines. Cov kev tshawb pom no hais txog ob lub luag haujlwm ntawm HBOT hauv kev txhim kho kev txawj ntse thaum tib lub sijhawm txo cov txheej txheem neuroinflammatory cuam tshuam nrog Alzheimer's disease.
Lwm cov qauv kev kho mob tau siv 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) nas los ntsuas cov txheej txheem tiv thaiv ntawm HBOT ntawm kev ua haujlwm neuronal thiab lub cev muaj zog. Cov txiaj ntsig tau qhia tias HBOT tau pab txhawb kev ua kom lub cev muaj zog thiab tuav lub zog hauv cov nas no, cuam tshuam nrog kev nce hauv mitochondrial biogenesis signaling, tshwj xeeb los ntawm kev ua kom SIRT-1, PGC-1α, thiab TFAM. Qhov no qhia txog lub luag haujlwm tseem ceeb ntawm mitochondrial muaj nuj nqi hauv cov teebmeem neuroprotective ntawm HBOT.
Cov Mechanisms ntawm HBOT hauv Cov Kab Mob Neurodegenerative
Lub hauv paus ntsiab lus ntawm kev siv HBOT rau NDDs yog nyob rau hauv kev sib raug zoo ntawm kev txo cov pa oxygen thiab qhov cuam tshuam rau kev hloov pauv neurodegenerative. Hypoxia-inducible factor-1 (HIF-1) plays lub luag haujlwm tseem ceeb hauv kev hloov pauv ntawm cov cellular adaptation rau cov pa oxygen tsawg thiab tau cuam tshuam rau ntau yam NDDs suav nrog AD, PD, Huntington's Disease, thiab ALS, kos npe tias nws yog lub hom phiaj tshuaj tseem ceeb.
Vim muaj hnub nyoog yog qhov tseem ceeb ntawm kev pheej hmoo rau ntau yam kab mob neurodegenerative, tshawb xyuas qhov cuam tshuam ntawm HBOT ntawm kev laus neurobiology yog qhov tseem ceeb. Cov kev tshawb fawb tau qhia tias HBOT tuaj yeem txhim kho cov hnub nyoog ntsig txog kev paub tsis zoo hauv cov neeg laus noj qab haus huv.Tsis tas li ntawd, cov neeg mob laus uas muaj qhov tsis nco qab tseem ceeb tau nthuav tawm kev paub txog kev txhim kho thiab nce ntshav cerebral ntws tom qab raug HBOT.
1. Kev cuam tshuam ntawm HBOT ntawm Kev Mob Ntsws thiab Oxidative Stress
HBOT tau qhia txog lub peev xwm los txo cov mob neuroinflamation hauv cov neeg mob uas muaj lub hlwb ua haujlwm tsis zoo. Nws muaj lub peev xwm los txo qis cov cytokines pro-inflammatory (xws li IL-1β, IL-12, TNFα, thiab IFNγ) thaum kho cov tshuaj tiv thaiv kab mob cytokines (xws li IL-10). Qee cov kws tshawb fawb tau tshaj tawm tias cov pa oxygen reactive (ROS) tsim los ntawm HBOT kho kom haum rau ntau qhov txiaj ntsig ntawm kev kho. Yog li ntawd, sib nrug los ntawm nws txoj kev ua npuas-txo lub siab thiab kev ua tiav ntawm cov ntaub so ntswg siab oxygen saturation, cov txiaj ntsig zoo txuas rau HBOT yog ib feem nyob ntawm lub luag haujlwm ntawm lub cev ntawm cov khoom tsim ROS.
2. Cov teebmeem ntawm HBOT ntawm Apoptosis thiab Neuroprotection
Kev tshawb fawb tau qhia tias HBOT tuaj yeem txo hippocampal phosphorylation ntawm p38 mitogen-activated protein kinase (MAPK), tom qab txhim kho kev paub thiab txo qis hippocampal kev puas tsuaj. Ob leeg standalone HBOT thiab ua ke nrog Ginkgo biloba extract tau pom tias txo qis kev qhia ntawm Bax thiab kev ua ntawm caspase-9/3, ua rau txo qis apoptosis tus nqi hauv nas qauv induced los ntawm aβ25-35. Tsis tas li ntawd, lwm txoj kev tshawb fawb pom tau hais tias HBOT preconditioning induced kam rau ua rau lub paj hlwb ischemia, nrog rau cov mechanisms uas muaj kev nce SIRT1 qhia, nrog rau augmented B-cell lymphoma 2 (Bcl-2) ntau ntau thiab txo active caspase-3, underscoring HBOT lub neuroprotective thiab anti-apoptotic zog.
3. Kev cuam tshuam ntawm HBOT ntawm Kev Tshaj Tawm thiabNeurogenesis
Kev nthuav tawm cov ntsiab lus rau HBOT tau cuam tshuam nrog ntau yam cuam tshuam ntawm cov hlab ntsha hauv lub cev, suav nrog kev txhim kho cov ntshav-hlwb barrier permeability, txhawb nqa angiogenesis, thiab txo edema. Ntxiv rau kev muab cov khoom siv oxygen ntxiv rau cov ntaub so ntswg, HBOTtxhawb nqa vascular tsimlos ntawm activating transcription yam xws li vascular endothelial kev loj hlob zoo thiab los ntawm stimulating proliferation ntawm neural qia hlwb.
4. Epigenetic teebmeem ntawm HBOT
Cov kev tshawb fawb tau qhia tias kev kis ntawm tib neeg microvascular endothelial hlwb (HMEC-1) rau hyperbaric oxygen tau tswj hwm 8,101 cov noob, suav nrog ob qho tib si upregulated thiab downregulated kab lus, qhia txog qhov nce hauv cov noob qhia cuam tshuam nrog cov kab mob antioxidant.
Xaus
Kev siv HBOT tau ua qhov tseem ceeb hauv lub sijhawm, ua pov thawj nws muaj, kev ntseeg tau, thiab kev nyab xeeb hauv kev kho mob. Thaum HBOT tau tshawb nrhiav raws li kev kho mob tsis muaj npe rau NDDs thiab qee qhov kev tshawb fawb tau ua tiav, tseem muaj qhov xav tau rau cov kev tshawb fawb nruj kom ua qauv HBOT kev coj ua hauv kev kho cov mob no. Kev tshawb fawb ntxiv yog qhov tseem ceeb los txiav txim siab qhov kev kho kom zoo dua qub thiab ntsuas qhov txiaj ntsig zoo rau cov neeg mob.
Hauv cov ntsiab lus, kev sib tshuam ntawm hyperbaric oxygen thiab cov kab mob neurodegenerative qhia tau hais tias muaj kev cia siab nyob rau hauv txoj kev kho mob, ua pov thawj txuas ntxiv tshawb nrhiav thiab siv tau hauv chaw kho mob.
Post lub sij hawm: May-16-2025