Ib Txoj Kev Zoo Siab Rau Cov Kab Mob Neurodegenerative: Hyperbaric Oxygen Therapy

To taub Hyperbaric Oxygen Therapy (HBOT)

Feem ntau HBOT yuav ua rau lub siab nce mus rau saum 1 absolute atmospheric (ATA) - lub siab ntawm dej hiav txwv - rau lub sijhawm 90-120 feeb, feem ntau yuav tsum tau ntau zaus nyob ntawm seb qhov mob twg kho. Lub siab ntawm huab cua zoo dua ua rau lub cev xa cov pa oxygen mus rau cov hlwb, uas ua rau cov hlwb loj hlob thiab ua rau cov txheej txheem kho mob zoo dua los ntawm qee yam kev loj hlob.

Chiv thawj, daim ntawv thov ntawm HBOT tau tsim los ntawm Boyle-Marriott txoj cai, uas hais txog kev txo qis ntawm cov pa roj, nrog rau cov txiaj ntsig ntawm cov pa oxygen siab hauv cov ntaub so ntswg. Muaj ntau yam kab mob uas paub tias tau txais txiaj ntsig los ntawm lub xeev hyperoxic tsim los ntawm HBOT, suav nrog cov ntaub so ntswg necrotic, kev raug mob hluav taws xob, kev raug mob, kub hnyiab, compartment syndrome, thiab roj gangrene, ntawm lwm tus teev los ntawm Undersea thiab Hyperbaric Medical Society. Qhov tseem ceeb, HBOT kuj tau qhia txog kev ua haujlwm zoo li kev kho mob ntxiv rau ntau yam kab mob inflammatory lossis kis kab mob, xws li colitis thiab sepsis. Muab nws cov txheej txheem tiv thaiv kev inflammatory thiab oxidative, HBOT muaj peev xwm tseem ceeb ua txoj hauv kev kho mob rau cov kab mob neurodegenerative.

 

Kev Kawm Ua Ntej ntawm Kev Kho Mob Hyperbaric Oxygen Therapy hauv Cov Kab Mob Neurodegenerative: Kev Nkag Siab los ntawm 3 × Tg Mouse Model

Ib qho ntawm cov kev tshawb fawb tseem ceebtsom mus rau tus qauv nas 3 × Tg ntawm tus kab mob Alzheimer (AD), uas tau qhia txog lub peev xwm kho mob ntawm HBOT hauv kev kho kom zoo dua qub. Kev tshawb fawb no muaj cov nas txiv neej 3 × Tg hnub nyoog 17 lub hlis piv rau cov nas txiv neej C57BL / 6 hnub nyoog 14 lub hlis ua tus tswj. Kev tshawb fawb tau qhia tias HBOT tsis yog tsuas yog txhim kho kev ua haujlwm ntawm kev paub xwb tab sis kuj txo qhov mob, plaque load, thiab Tau phosphorylation - ib qho txheej txheem tseem ceeb uas cuam tshuam nrog AD pathology.

Cov txiaj ntsig tiv thaiv ntawm HBOT tau raug suav hais tias yog vim muaj kev txo qis ntawm neuroinflammation. Qhov no tau ua pov thawj los ntawm kev txo qis ntawm microglial proliferation, astrogliosis, thiab kev tso tawm ntawm pro-inflammatory cytokines. Cov kev tshawb pom no hais txog lub luag haujlwm ob ntawm HBOT hauv kev txhim kho kev ua haujlwm ntawm kev paub thaum tib lub sijhawm txo cov txheej txheem neuroinflammatory cuam tshuam nrog Alzheimer's tus kab mob.

Lwm tus qauv ua ntej siv tshuaj siv cov nas 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) los ntsuam xyuas cov txheej txheem tiv thaiv ntawm HBOT ntawm kev ua haujlwm ntawm lub paj hlwb thiab lub peev xwm ntawm lub cev. Cov txiaj ntsig qhia tau hais tias HBOT tau pab txhawb kev ua haujlwm ntawm lub cev thiab lub zog tuav ntawm cov nas no, sib raug zoo nrog kev nce ntxiv ntawm mitochondrial biogenesis signaling, tshwj xeeb tshaj yog los ntawm kev ua haujlwm ntawm SIRT-1, PGC-1α, thiab TFAM. Qhov no qhia txog lub luag haujlwm tseem ceeb ntawm mitochondrial kev ua haujlwm hauv cov teebmeem neuroprotective ntawm HBOT.

 

Cov Mechanisms ntawm HBOT hauv Neurodegenerative Diseases

Lub hauv paus ntsiab lus ntawm kev siv HBOT rau NDDs yog nyob rau hauv kev sib raug zoo ntawm kev txo qis cov pa oxygen thiab qhov kev cuam tshuam rau kev hloov pauv neurodegenerative. Hypoxia-inducible factor-1 (HIF-1) ua lub luag haujlwm tseem ceeb ua tus lej sau ntawv uas ua rau lub hlwb hloov kho rau qhov tsis tshua muaj pa oxygen thiab tau koom nrog ntau yam NDDs suav nrog AD, PD, Huntington's Disease, thiab ALS, cim nws ua lub hom phiaj tseem ceeb ntawm tshuaj.

Vim tias hnub nyoog yog ib qho tseem ceeb uas ua rau muaj ntau yam kab mob neurodegenerative, kev tshawb nrhiav qhov cuam tshuam ntawm HBOT rau kev laus neurobiology yog qhov tseem ceeb heev. Cov kev tshawb fawb tau qhia tias HBOT tuaj yeem txhim kho cov teeb meem kev paub txog hnub nyoog hauv cov neeg laus noj qab haus huv.Tsis tas li ntawd xwb, cov neeg mob laus uas muaj teeb meem nco qab tseem ceeb tau pom tias muaj kev txhim kho kev paub thiab kev ntws ntshav hauv lub hlwb ntau ntxiv tom qab raug HBOT.

 

1. Kev cuam tshuam ntawm HBOT rau kev o thiab kev ntxhov siab oxidative

HBOT tau ua pov thawj tias muaj peev xwm txo qhov mob neuroinflammation rau cov neeg mob uas muaj teeb meem loj heev ntawm lub hlwb. Nws muaj peev xwm txo cov cytokines pro-inflammatory (xws li IL-1β, IL-12, TNFα, thiab IFNγ) thaum nce cov cytokines anti-inflammatory (xws li IL-10). Qee cov kws tshawb fawb hais tias cov tshuaj reactive oxygen (ROS) uas tsim los ntawm HBOT ua rau muaj ntau yam txiaj ntsig zoo ntawm kev kho mob. Yog li ntawd, sib nrug los ntawm nws qhov kev ua haujlwm txo cov npuas siab thiab kev ua tiav ntawm cov ntaub so ntswg oxygen saturation siab, cov txiaj ntsig zoo txuas nrog HBOT yog ib feem nyob ntawm lub luag haujlwm ntawm lub cev ntawm ROS tsim tawm.

2. Cov teebmeem ntawm HBOT rau Apoptosis thiab Neuroprotection

Kev tshawb fawb tau qhia tias HBOT tuaj yeem txo qhov hippocampal phosphorylation ntawm p38 mitogen-activated protein kinase (MAPK), tom qab ntawd txhim kho kev paub thiab txo qhov puas tsuaj ntawm hippocampal. Ob qho tib si standalone HBOT thiab ua ke nrog Ginkgo biloba extract tau pom tias txo qhov kev qhia tawm ntawm Bax thiab kev ua haujlwm ntawm caspase-9/3, ua rau cov nqi apoptosis txo qis hauv cov qauv rodent uas tshwm sim los ntawm aβ25-35. Ntxiv mus, lwm txoj kev tshawb fawb tau qhia tias HBOT preconditioning ua rau muaj kev kam rau siab tiv thaiv cerebral ischemia, nrog rau cov txheej txheem uas muaj kev nce SIRT1 kev qhia tawm, nrog rau cov qib B-cell lymphoma 2 (Bcl-2) thiab txo cov caspase-3 nquag, qhia txog HBOT cov khoom neuroprotective thiab anti-apoptotic.

3. Kev cuam tshuam ntawm HBOT rau kev ncig thiabKev tsim cov hlab ntsha hauv lub hlwb

Kev raug cov neeg raug HBOT tau cuam tshuam nrog ntau yam teebmeem rau lub cev ntawm lub hlwb, suav nrog kev txhim kho cov ntshav-lub hlwb permeability, txhawb angiogenesis, thiab txo qhov o. Ntxiv rau kev muab cov pa oxygen ntau ntxiv rau cov ntaub so ntswg, HBOTtxhawb kev tsim cov hlab ntshalos ntawm kev ua kom cov yam ntxwv transcription xws li vascular endothelial growth factor thiab los ntawm kev txhawb nqa kev loj hlob ntawm cov hlwb neural stem cell.

4. Cov teebmeem epigenetic ntawm HBOT

Cov kev tshawb fawb tau qhia tias kev raug rau cov hlwb endothelial microvascular ntawm tib neeg (HMEC-1) rau cov pa oxygen hyperbaric tswj hwm 8,101 noob caj noob ces, suav nrog ob qho tib si kev qhia tawm upregulated thiab downregulated, qhia txog kev nce ntxiv ntawm kev qhia tawm noob caj noob ces cuam tshuam nrog cov kab mob antioxidant.