Hauv thaj chaw ntawm cov tshuaj niaj hnub no, cov tshuaj tua kab mob tau ua pov thawj tias yog ib qho kev nce qib tseem ceeb tshaj plaws, txo qis qhov tshwm sim thiab kev tuag ntawm cov kab mob microbial. Lawv lub peev xwm los hloov kho qhov tshwm sim ntawm cov kab mob kab mob tau txuas ntxiv lub neej ntawm cov neeg mob suav tsis txheeb. Cov tshuaj tua kab mob yog ib qho tseem ceeb hauv cov txheej txheem kho mob, suav nrog kev phais, kev tso chaw cog qoob loo, hloov pauv, thiab tshuaj tua kab mob. Txawm li cas los xij, qhov tshwm sim ntawm cov tshuaj tua kab mob tiv thaiv kab mob tau ua rau muaj kev txhawj xeeb zuj zus, txo qis cov txiaj ntsig ntawm cov tshuaj no dhau sijhawm. Cov xwm txheej ntawm cov tshuaj tiv thaiv kab mob tau sau tseg thoob plaws txhua pawg ntawm cov tshuaj tua kab mob raws li kev hloov pauv microbial tshwm sim. Kev xaiv lub siab los ntawm cov tshuaj tiv thaiv kab mob tau ua rau muaj kev tiv thaiv kab mob, ua rau muaj kev sib tw tseem ceeb rau kev noj qab haus huv thoob ntiaj teb.
Txhawm rau tiv thaiv qhov teeb meem nyuaj ntawm cov tshuaj tiv thaiv kab mob, nws yog ib qho tseem ceeb rau kev siv cov cai tswj kev kis kab mob zoo uas txwv tsis pub kis tus kab mob tiv thaiv, nrog rau txo kev siv tshuaj tua kab mob. Tsis tas li ntawd, muaj kev xav tau rau lwm txoj kev kho mob. Hyperbaric Oxygen Therapy (HBOT) tau tshwm sim los ua qhov kev cog lus zoo hauv cov ntsiab lus no, suav nrog kev nqus pa ntawm 100% oxygen ntawm cov qib siab tshwj xeeb rau lub sijhawm. Raws li txoj haujlwm tseem ceeb lossis kev kho mob ntxiv rau kev kis kab mob, HBOT tuaj yeem muaj kev cia siab tshiab hauv kev kho mob hnyav los ntawm cov kab mob tiv thaiv kab mob.
Txoj kev kho no tau siv ntau dua los ua thawj lossis lwm txoj kev kho mob rau ntau yam mob, suav nrog kev mob o, carbon monoxide lom, mob ntev, kab mob ischemic, thiab kab mob. Cov kev siv tshuaj kho mob ntawm HBOT hauv kev kho kab mob yog qhov muaj txiaj ntsig zoo, muab txiaj ntsig zoo rau cov neeg mob.
Kev siv tshuaj kho mob ntawm Hyperbaric Oxygen Therapy hauv Kab Mob
Cov pov thawj tam sim no txhawb nqa daim ntawv thov HBOT, ob qho tib si ua ib leeg thiab kev kho mob ntxiv, nthuav qhia cov txiaj ntsig tseem ceeb rau cov neeg mob. Thaum lub sij hawm HBOT, arterial ntshav oxygen siab tuaj yeem nce mus rau 2000 mmHg, thiab qhov tshwm sim ntawm cov pa oxygen siab siab gradient tuaj yeem nce cov pa oxygen mus rau 500 mmHg. Cov teebmeem zoo li no muaj txiaj ntsig tshwj xeeb hauv kev txhawb nqa kev kho mob ntawm cov lus teb inflammatory thiab microcirculatory cuam tshuam tau pom nyob rau hauv ib puag ncig ischemic, nrog rau kev tswj cov kab mob hauv lub cev.
HBOT kuj tseem tuaj yeem cuam tshuam cov xwm txheej ntawm lub cev tiv thaiv kab mob. Kev tshawb fawb qhia tias HBOT tuaj yeem cuam tshuam cov kab mob autoimmune thiab cov tshuaj tiv thaiv kab mob tiv thaiv kab mob, pab tswj kev noj qab haus huv los ntawm kev txo qis cov lymphocytes thiab leukocytes thaum hloov kho lub cev tiv thaiv kab mob. Tsis tas li ntawd, HBOTtxhawb kev kho mobnyob rau hauv cov tawv nqaij mob ntev los ntawm stimulating angiogenesis, txheej txheem tseem ceeb rau kev txhim kho kev rov zoo. Qhov kev kho no kuj txhawb kev tsim ntawm collagen matrix, ib theem tseem ceeb hauv kev kho qhov txhab.
Kev saib xyuas tshwj xeeb yuav tsum tau muab rau qee yam kab mob, tshwj xeeb tshaj yog cov kab mob sib sib zog nqus thiab nyuaj rau kev kho mob xws li necrotizing fasciitis, osteomyelitis, mob nqaij mos, thiab kab mob endocarditis. Ib qho ntawm cov kev siv tshuaj kho mob ntau tshaj plaws ntawm HBOT yog rau cov kab mob ntawm daim tawv nqaij mos thiab osteomyelitis cuam tshuam nrog cov pa oxygen tsawg uas feem ntau tshwm sim los ntawm cov kab mob anaerobic lossis resistant.
1. Mob ntshav qab zib ko taw
Mob ntshav qab zib ko tawulcers yog ib qho teeb meem ntawm cov neeg mob ntshav qab zib, cuam tshuam txog li 25% ntawm cov neeg no. Cov kab mob feem ntau tshwm sim hauv cov kab mob no (suav txog 40%-80% ntawm cov neeg mob) thiab ua rau muaj kev mob hnyav ntxiv thiab kev tuag. Mob ntshav qab zib ko taw (DFIs) feem ntau muaj cov kab mob polymicrobial nrog ntau hom kab mob anaerobic kab mob uas tau txheeb xyuas. Ntau yam, suav nrog fibroblast kev ua haujlwm tsis xws luag, teeb meem tsim collagen, cellular tiv thaiv kab mob, thiab phagocyte muaj nuj nqi, tuaj yeem cuam tshuam qhov txhab kho hauv cov neeg mob ntshav qab zib. Ntau qhov kev tshawb fawb tau txheeb xyuas cov tawv nqaij tsis zoo oxygenation raws li qhov muaj feem cuam tshuam rau kev txiav txim siab txog DFIs.
Raws li ib qho ntawm cov kev xaiv tam sim no rau kev kho DFI, HBOT tau raug tshaj tawm los txhim kho kev kho tus nqi kho mob rau cov mob ntshav qab zib ko taw, tom qab ntawd txo qhov kev xav tau ntawm kev txiav tawm thiab cov kev phais nyuaj. Nws tsis tsuas yog txo qhov tsim nyog rau cov txheej txheem siv nyiaj ntau, xws li kev phais lub ntsej muag thiab cov tawv nqaij grafting, tab sis kuj nthuav tawm cov nqi qis thiab cov kev mob tshwm sim tsawg dua piv rau cov kev xaiv phais. Kev tshawb fawb los ntawm Chen et al. pom tau hais tias ntau tshaj 10 zaug ntawm HBOT ua rau 78.3% kev txhim kho ntawm qhov txhab kho mob hauv cov neeg mob ntshav qab zib.
2. Necrotizing cov ntaub so ntswg mos
Cov kab mob necrotizing mos mos (NSTIs) feem ntau yog polymicrobial, feem ntau tshwm sim los ntawm kev sib xyaw ua ke ntawm cov kab mob aerobic thiab anaerobic kab mob thiab feem ntau cuam tshuam nrog kev tsim roj. Thaum NSTIs tsis tshua muaj, lawv nthuav tawm cov neeg tuag coob vim lawv txoj kev loj hlob sai. Kev kuaj mob raws sij hawm thiab tsim nyog thiab kev kho mob yog qhov tseem ceeb rau kev ua tiav cov txiaj ntsig zoo, thiab HBOT tau raug pom zoo los ua ib txoj hauv kev rau kev tswj hwm NSTIs. Txawm hais tias tseem muaj kev sib cav sib ceg nyob ib puag ncig HBOT kev siv hauv NSTIs vim tsis muaj kev soj ntsuam yav tom ntej,Cov ntaub ntawv pov thawj qhia tias nws tuaj yeem cuam tshuam nrog kev txhim kho kev ciaj sia thiab kev khaws cia hauv nruab nrog cev hauv NSTI cov neeg mob. Kev tshawb nrhiav rov qab tau qhia txog qhov txo qis hauv kev tuag ntawm cov neeg mob NSTI tau txais HBOT.
1.3 Kev phais mob ntawm qhov chaw
SSIs tuaj yeem raug cais raws li qhov chaw kuaj mob ntawm tus kab mob thiab tuaj yeem tshwm sim los ntawm ntau yam kab mob, suav nrog cov kab mob aerobic thiab anaerobic. Txawm hais tias muaj kev nce qib hauv kev tiv thaiv kab mob, xws li kev ua kom tsis muaj menyuam, kev siv tshuaj tua kab mob tiv thaiv kab mob, thiab kev txhim kho hauv kev phais mob, SSIs tseem muaj teeb meem tsis tu ncua.
Ib qho kev tshuaj xyuas tseem ceeb tau tshawb xyuas qhov ua tau zoo ntawm HBOT hauv kev tiv thaiv kev sib sib zog nqus SSIs hauv kev phais neuromuscular scoliosis. Preoperative HBOT tuaj yeem txo qhov tshwm sim ntawm SSIs thiab pab kho qhov txhab. Qhov kev kho uas tsis yog-invasive no tsim ib qho chaw uas cov pa oxygen hauv cov ntaub so ntswg tau nce siab, uas tau cuam tshuam nrog oxidative tua tawm tsam cov kab mob. Tsis tas li ntawd, nws hais txog cov ntshav qis thiab cov pa oxygen uas ua rau kev loj hlob ntawm SSIs. Tshaj li lwm cov tswv yim tswj kev kis kab mob, HBOT tau raug pom zoo tshwj xeeb rau kev phais kom huv si xws li cov txheej txheem hauv plab hnyuv.
1.4 Burns
Kev kub hnyiab yog kev raug mob los ntawm huab cua kub, hluav taws xob tam sim no, tshuaj lom neeg, lossis hluav taws xob thiab tuaj yeem ua rau muaj mob hnyav thiab tuag taus. HBOT muaj txiaj ntsig zoo hauv kev kho mob kub hnyiab los ntawm kev nce qib oxygen hauv cov ntaub so ntswg puas. Thaum cov kev tshawb fawb tsiaj thiab chaw kho mob nthuav tawm cov txiaj ntsig sib xyaw txogqhov ua tau zoo ntawm HBOT hauv kev kho mob kub hnyiab, ib txoj kev tshawb fawb uas muaj 125 tus neeg mob kub hnyiab tau qhia tias HBOT tsis pom muaj kev cuam tshuam loj rau cov neeg tuag los yog tus lej ntawm kev phais tab sis tau txo lub sij hawm kho mob nruab nrab (19.7 hnub piv rau 43.8 hnub). Kev koom ua ke HBOT nrog kev tswj hwm kev kub hnyiab tuaj yeem tswj tau cov kab mob sepsis hauv cov neeg mob kub hnyiab, ua rau lub sijhawm kho kom luv thiab txo cov kua dej. Txawm li cas los xij, kev tshawb fawb txuas ntxiv yuav tsum tau ua kom paub meej tias lub luag haujlwm ntawm HBOT hauv kev tswj hwm qhov kub hnyiab.
1.5 Osteomyelitis
Osteomyelitis yog ib qho kab mob ntawm cov pob txha lossis pob txha pob txha feem ntau tshwm sim los ntawm cov kab mob kab mob. Kev kho osteomyelitis tuaj yeem nyuaj vim cov ntshav tsis zoo rau cov pob txha thiab qhov txwv tsis pub nkag mus rau cov tshuaj tua kab mob rau hauv cov pob txha. Cov kab mob osteomyelitis ntev yog tshwm sim los ntawm cov kab mob tsis tu ncua, mob me me, thiab tsim cov pob txha necrotic. Refractory osteomyelitis yog hais txog cov kab mob pob txha ntev uas txuas ntxiv lossis rov zoo dua txawm tias muaj kev kho mob tsim nyog.
HBOT tau pom tias yuav txhim kho cov pa oxygen hauv cov pob txha muaj kab mob. Ntau qhov xwm txheej thiab cov kev tshawb fawb hauv pawg qhia tias HBOT txhim kho cov txiaj ntsig kev kho mob rau cov neeg mob osteomyelitis. Nws zoo nkaus li ua haujlwm los ntawm ntau yam txheej txheem, suav nrog kev txhawb nqa kev ua haujlwm hauv metabolic, tshem tawm cov kab mob pathogens, txhim kho cov tshuaj tua kab mob, txo qis qhov mob, thiab txhawb kev kho mob.txheej txheem. Tom qab HBOT, 60% mus rau 85% ntawm cov neeg mob uas mob ntev, refractory osteomyelitis qhia cov tsos mob ntawm kev tiv thaiv kab mob.
1.6 Cov kab mob fungal
Thoob plaws ntiaj teb, ntau dua peb lab tus tib neeg raug kev txom nyem los ntawm kev mob ntev lossis kis kab mob fungal, ua rau ntau dua 600,000 tus neeg tuag txhua xyoo. Cov txiaj ntsig kev kho mob rau cov kab mob fungal feem ntau cuam tshuam los ntawm cov xwm txheej xws li hloov pauv lub cev tsis muaj zog, kab mob hauv qab, thiab cov yam ntxwv ntawm cov kab mob virulence. HBOT tau dhau los ua qhov kev xaiv kho kom zoo nkauj hauv cov kab mob fungal hnyav vim nws txoj kev nyab xeeb thiab tsis muaj kev cuam tshuam. Cov kev tshawb fawb qhia tias HBOT tuaj yeem tiv thaiv cov kab mob fungal xws li Aspergillus thiab Mycobacterium tuberculosis.
HBOT txhawb nqa cov tshuaj tiv thaiv kab mob los ntawm inhibiting biofilm tsim ntawm Aspergillus, nrog rau kev ua tau zoo tau sau tseg hauv hom tsis muaj superoxide dismutase (SOD) noob. Cov mob hypoxic thaum muaj kab mob fungal ua rau muaj teeb meem rau kev xa tshuaj tiv thaiv kab mob, ua kom cov pa oxygen ntau ntxiv los ntawm HBOT muaj txiaj ntsig zoo, txawm hais tias kev tshawb fawb ntxiv tau lees paub.
Antimicrobial Properties ntawm HBOT
Ib puag ncig hyperoxic tsim los ntawm HBOT pib hloov lub cev thiab biochemical hloov pauv uas txhawb nqa cov kab mob tua kab mob, ua rau nws muaj txiaj ntsig zoo rau kev tiv thaiv kab mob. HBOT qhia tau hais tias muaj txiaj ntsig zoo rau cov kab mob aerobic thiab feem ntau cov kab mob anaerobic los ntawm cov txheej txheem xws li kev ua haujlwm ntawm cov kab mob ncaj qha, txhim kho kev tiv thaiv kab mob, thiab kev sib koom ua ke nrog cov tshuaj tua kab mob tshwj xeeb.
2.1 Direct Antibacterial Effects ntawm HBOT
Cov tshuaj tua kab mob ncaj qha ntawm HBOT feem ntau tshwm sim los ntawm kev tsim cov pa oxygen reactive (ROS), uas suav nrog superoxide anions, hydrogen peroxide, hydroxyl radicals, thiab hydroxyl ions - tag nrho cov uas tshwm sim thaum lub sij hawm cellular metabolism.
Kev sib cuam tshuam ntawm O₂ thiab cellular Cheebtsam yog qhov tseem ceeb hauv kev nkag siab tias ROS ua li cas hauv cov hlwb. Raws li qee qhov xwm txheej hu ua oxidative kev nyuaj siab, qhov sib npaug ntawm ROS tsim thiab nws cov degradation raug cuam tshuam, ua rau nce qib ntawm ROS hauv hlwb. Kev tsim cov superoxide (O₂⁻) yog catalyzed los ntawm superoxide dismutase, uas tom qab hloov O₂⁻ mus rau hydrogen peroxide (H₂O₂). Qhov kev hloov dua siab tshiab no tau nthuav dav ntxiv los ntawm Fenton cov tshuaj tiv thaiv, uas oxidizes Fe²⁺ los tsim hydroxyl radicals (·OH) thiab Fe³⁺, yog li pib muaj kev cuam tshuam redox sequence ntawm ROS tsim thiab cellular puas.
Cov teebmeem tshuaj lom ntawm ROS lub hom phiaj tseem ceeb ntawm cov cellular xws li DNA, RNA, cov proteins, thiab lipids. Tshwj xeeb tshaj yog, DNA yog lub hom phiaj tseem ceeb ntawm H₂O₂-mediated cytotoxicity, vim nws cuam tshuam cov qauv deoxyribose thiab ua rau cov hauv paus muaj kev puas tsuaj. Lub cev puas tsuaj los ntawm ROS txuas mus rau helix qauv ntawm DNA, uas tshwm sim los ntawm lipid peroxidation tshwm sim los ntawm ROS. Qhov no qhia txog qhov tshwm sim tsis zoo ntawm qib siab ROS hauv cov kab ke lom neeg.
Antimicrobial Action ntawm ROS
ROS ua lub luag haujlwm tseem ceeb hauv inhibiting microbial kev loj hlob, raws li pom los ntawm HBOT-induced ROS tiam. Cov teebmeem tshuaj lom ntawm ROS ncaj qha rau cov khoom siv cellular xws li DNA, proteins, thiab lipids. Kev ua haujlwm siab ntawm cov pa oxygen tuaj yeem cuam tshuam ncaj qha rau lipids, ua rau lipid peroxidation. Cov txheej txheem no cuam tshuam qhov kev ncaj ncees ntawm cov cell membranes thiab, yog li ntawd, kev ua haujlwm ntawm daim nyias nyias nrog cov receptors thiab cov proteins.
Tsis tas li ntawd, cov proteins, uas tseem yog lub hom phiaj tseem ceeb ntawm ROS, tau txais kev hloov kho oxidative tshwj xeeb ntawm ntau cov amino acid residues xws li cysteine, methionine, tyrosine, phenylalanine, thiab tryptophan. Piv txwv li, HBOT tau pom tias yuav ua rau muaj kev hloov pauv oxidative hauv ntau cov proteins hauv E. coli, suav nrog elongation factor G thiab DnaK, yog li cuam tshuam rau lawv txoj haujlwm ntawm tes.
Txhim khu kev tiv thaiv los ntawm HBOT
Anti-inflammatory zog ntawm HBOTtau raug sau tseg, ua pov thawj tseem ceeb rau kev txo cov ntaub so ntswg puas thiab suppressing kis kab mob. HBOT cuam tshuam qhov kev qhia ntawm cytokines thiab lwm yam inflammatory regulators, cuam tshuam lub cev tiv thaiv kab mob. Ntau yam kev sim ntsuas pom qhov sib txawv ntawm cov noob qhia thiab cov protein ntau tom qab HBOT, uas yog upregulate lossis downregulate loj hlob yam thiab cytokines.
Thaum lub sij hawm HBOT txheej txheem, nce O₂ qib ua rau muaj ntau yam ntawm cov lus teb ntawm tes, xws li txwv tsis pub tso tawm cov neeg kho mob pro-inflammatory thiab txhawb nqa lymphocyte thiab neutrophil apoptosis. Ua ke, cov kev ua no txhim kho lub cev tiv thaiv kab mob antimicrobial mechanisms, yog li ua kom yooj yim kho cov kab mob.
Tsis tas li ntawd, cov kev tshawb fawb qhia tias kev nce qib O₂ thaum HBOT tuaj yeem txo qhov kev qhia ntawm pro-inflammatory cytokines, suav nrog interferon-gamma (IFN-γ), interleukin-1 (IL-1), thiab interleukin-6 (IL-6). Cov kev hloov pauv no tseem suav nrog txo qis qhov sib piv ntawm CD4: CD8 T hlwb thiab hloov pauv lwm cov soluble receptors, thaum kawg nce qib interleukin-10 (IL-10), uas yog qhov tseem ceeb rau kev tiv thaiv kev mob thiab txhawb kev kho mob.
Cov dej tshuaj tiv thaiv kab mob ntawm HBOT muaj kev cuam tshuam nrog cov txheej txheem lom neeg. Ob qho tib si superoxide thiab siab siab tau raug tshaj tawm kom tsis tu ncua txhawb HBOT-induced antibacterial kev ua si thiab neutrophil apoptosis. Tom qab HBOT, ib qho kev nce qib hauv cov pa oxygen txhim kho cov kab mob bactericidal ntawm neutrophils, ib qho tseem ceeb ntawm kev tiv thaiv kab mob. Tsis tas li ntawd, HBOT suppresses neutrophil adhesion, uas yog kho los ntawm kev sib cuam tshuam ntawm β-integrins ntawm neutrophils nrog intercellular adhesion molecules (ICAM) ntawm cov hlwb endothelial. HBOT inhibits qhov kev ua ntawm neutrophil β-2 integrin (Mac-1, CD11b / CD18) los ntawm cov txheej txheem nitric oxide (NO)-kev sib kho, pab txhawb kev tsiv teb tsaws ntawm neutrophils mus rau qhov chaw kis kab mob.
Qhov tseeb rov kho ntawm cytoskeleton yog qhov tsim nyog rau neutrophils kom phagocytize cov kab mob zoo. S-nitrosylation ntawm actin tau pom tias yuav txhawb nqa actin polymerization, muaj peev xwm ua kom yooj yim rau phagocytic kev ua ntawm neutrophils tom qab HBOT ua ntej kho. Ntxiv mus, HBOT txhawb nqa apoptosis nyob rau hauv tib neeg T cell kab los ntawm txoj kev mitochondrial, nrog ceev lymphocyte tuag tom qab HBOT raug tshaj tawm. Thaiv caspase-9-tsis muaj kev cuam tshuam caspase-8- tau ua kom pom cov tshuaj tiv thaiv kab mob ntawm HBOT.
Lub Synergistic Effects ntawm HBOT nrog Antimicrobial Agents
Hauv kev siv tshuaj kho mob, HBOT feem ntau siv nrog rau cov tshuaj tua kab mob los tiv thaiv kab mob kom zoo. Lub xeev hyperoxic ua tiav thaum HBOT tuaj yeem cuam tshuam qhov kev ua tau zoo ntawm qee yam tshuaj tua kab mob. Kev tshawb fawb qhia tias cov tshuaj tua kab mob tshwj xeeb, xws li β-lactams, fluoroquinolones, thiab aminoglycosides, tsis yog tsuas yog ua los ntawm cov txheej txheem tsim nyog tab sis kuj vam khom ib feem ntawm cov kab mob aerobic metabolism. Yog li ntawd, lub xub ntiag ntawm oxygen thiab cov yam ntxwv metabolic ntawm cov kab mob yog qhov tseem ceeb thaum ntsuas kev kho mob ntawm cov tshuaj tua kab mob.
Cov pov thawj tseem ceeb tau pom tias cov pa oxygen tsawg tuaj yeem ua rau muaj kev tiv thaiv ntawm Pseudomonas aeruginosa rau piperacillin / tazobactam thiab qhov chaw muaj pa oxygen tsawg kuj ua rau muaj zog tiv thaiv Enterobacter cloacae rau azithromycin. Hloov pauv, qee yam mob hypoxic tuaj yeem txhim kho cov kab mob rhiab heev rau tetracycline tshuaj tua kab mob. HBOT ua haujlwm raws li txoj kev kho mob uas siv tau los ntawm kev ua kom cov metabolism hauv aerobic thiab reoxygenating hypoxic cov ntaub so ntswg, tom qab ntawd ua rau cov kab mob rhiab heev rau cov tshuaj tua kab mob.
Hauv kev tshawb fawb ua ntej, kev sib xyaw ua ke ntawm HBOT - siv ob zaug ib hnub rau 8 teev ntawm 280 kPa - nrog rau tobramycin (20 mg / kg / hnub) txo qis cov kab mob hauv Staphylococcus aureus kis kab mob endocarditis. Qhov no qhia tau hais tias muaj peev xwm ntawm HBOT ua ib qho kev pab kho mob. Kev tshawb fawb ntxiv tau qhia tias nyob rau hauv 37 ° C thiab 3 ATA siab rau 5 teev, HBOT tseem ceeb txhim kho cov teebmeem ntawm imipenem tawm tsam macrophage-infected Pseudomonas aeruginosa. Tsis tas li ntawd, kev sib xyaw ua ke ntawm HBOT nrog cephazolin tau pom tias muaj txiaj ntsig zoo hauv kev kho Staphylococcus aureus osteomyelitis hauv cov qauv tsiaj piv rau cephazolin ib leeg.
HBOT kuj tseem ua kom cov kab mob tua kab mob ntawm ciprofloxacin tawm tsam Pseudomonas aeruginosa biofilms, tshwj xeeb tshaj yog tom qab 90 feeb ntawm kev raug. Qhov kev txhim kho no yog ntaus nqi los ntawm kev tsim cov kab mob endogenous reactive oxygen (ROS) thiab qhia txog qhov ua tau zoo hauv peroxidase-tsis zoo mutants.
Hauv cov qauv ntawm cov kab mob pleuritis tshwm sim los ntawm methicillin-resistant Staphylococcus aureus (MRSA), kev sib koom ua ke ntawm vancomycin, teicoplanin, thiab linezolid nrog HBOT pom tau tias muaj txiaj ntsig zoo tiv thaiv MRSA. Metronidazole, ib qho tshuaj tua kab mob siv dav hauv kev kho mob hnyav anaerobic thiab polymicrobial kab mob xws li mob ntshav qab zib ko taw (DFIs) thiab kab mob ntawm qhov chaw phais (SSIs), tau nthuav tawm cov tshuaj tua kab mob ntau dua nyob rau hauv cov xwm txheej anaerobic. Cov kev tshawb fawb yav tom ntej tau lees paub los tshawb nrhiav cov tshuaj tiv thaiv kab mob sib xyaw ua ke ntawm HBOT ua ke nrog metronidazole hauv ob qho tib si hauv vivo thiab hauv vitro chaw.
Antimicrobial Efficacy ntawm HBOT ntawm cov kab mob tiv taus
Nrog rau evolution thiab kis ntawm cov kab mob resistant, cov tshuaj tua kab mob feem ntau poob lawv cov potency thaum lub sij hawm. Tsis tas li ntawd, HBOT tuaj yeem ua pov thawj qhov tseem ceeb hauv kev kho thiab tiv thaiv kev kis kab mob los ntawm cov kab mob ntau yam tshuaj tiv thaiv kab mob, ua lub tswv yim tseem ceeb thaum kev kho tshuaj tua kab mob ua tsis tiav. Ntau cov kev tshawb fawb tau tshaj tawm txog qhov tseem ceeb ntawm cov kab mob bactericidal ntawm HBOT ntawm cov kab mob uas muaj feem cuam tshuam rau kev kho mob. Piv txwv li, 90-feeb HBOT kev sib tham ntawm 2 ATM tau txo qis kev loj hlob ntawm MRSA. Tsis tas li ntawd, hauv cov qauv piv, HBOT tau txhim kho cov kab mob tua kab mob ntawm ntau yam tshuaj tua kab mob tiv thaiv kab mob MRSA. Cov ntawv ceeb toom tau lees paub tias HBOT muaj txiaj ntsig zoo hauv kev kho mob osteomyelitis tshwm sim los ntawm OXA-48-ua Klebsiella pneumoniae yam tsis tas yuav muaj cov tshuaj tua kab mob ntxiv.
Hauv cov ntsiab lus, kev kho mob hyperbaric oxygen sawv cev rau ntau txoj hauv kev los tswj kev kis kab mob, txhim kho lub cev tiv thaiv kab mob thaum tseem ua kom muaj txiaj ntsig ntawm cov tshuaj tua kab mob uas twb muaj lawm. Nrog rau kev tshawb fawb thiab kev loj hlob, nws tuav lub peev xwm los txo cov teebmeem ntawm cov tshuaj tua kab mob, muab kev cia siab rau kev sib ntaus sib tua tsis tu ncua tiv thaiv kab mob.
Post lub sij hawm: Feb-28-2025