Hauv kev kho mob niaj hnub no, cov tshuaj tua kab mob tau ua pov thawj tias yog ib qho ntawm kev nce qib tseem ceeb tshaj plaws, txo qis qhov tshwm sim thiab kev tuag ntawm cov kab mob me me. Lawv lub peev xwm los hloov cov txiaj ntsig kho mob ntawm cov kab mob me me tau ua rau lub neej ntev ntawm ntau tus neeg mob. Cov tshuaj tua kab mob yog qhov tseem ceeb hauv cov txheej txheem kho mob nyuaj, suav nrog kev phais, kev cog cov noob, kev hloov pauv, thiab kev kho mob chemotherapy. Txawm li cas los xij, kev tshwm sim ntawm cov kab mob uas tiv taus tshuaj tua kab mob tau ua rau muaj kev txhawj xeeb ntau ntxiv, ua rau cov tshuaj no tsis ua haujlwm zoo. Cov piv txwv ntawm kev tiv taus tshuaj tua kab mob tau sau tseg thoob plaws txhua pawg tshuaj tua kab mob thaum muaj kev hloov pauv ntawm cov kab mob me me. Kev xaiv cov tshuaj tua kab mob tau ua rau muaj kev nce ntxiv ntawm cov kab mob uas tiv taus, ua rau muaj kev cov nyom loj rau kev noj qab haus huv thoob ntiaj teb.
Yuav kom tiv thaiv tau qhov teeb meem ntawm kev tiv thaiv kab mob, nws yog ib qho tseem ceeb uas yuav tsum siv cov cai tswj kev kis kab mob kom zoo uas tiv thaiv kev kis tus kab mob uas tiv taus, nrog rau kev txo kev siv tshuaj tua kab mob. Tsis tas li ntawd xwb, muaj kev xav tau kev kho mob lwm yam. Hyperbaric Oxygen Therapy (HBOT) tau tshwm sim los ua ib txoj kev kho mob zoo hauv qhov no, uas cuam tshuam nrog kev nqus pa oxygen 100% ntawm cov qib siab tshwj xeeb rau ib lub sijhawm. HBOT yog ib qho kev kho mob tseem ceeb lossis kev kho mob ntxiv rau kev kis kab mob, nws yuav muab kev cia siab tshiab rau kev kho cov kab mob hnyav uas tshwm sim los ntawm cov kab mob uas tiv taus tshuaj tua kab mob.
Txoj kev kho mob no tau siv ntau zuj zus los ua kev kho mob tseem ceeb lossis lwm txoj kev kho mob rau ntau yam mob, suav nrog kev o, kev lom carbon monoxide, cov qhov txhab ntev, cov kab mob ischemic, thiab kev kis kab mob. Cov kev siv HBOT hauv kev kho mob kis kab mob yog qhov tob heev, muab cov txiaj ntsig zoo rau cov neeg mob.
Cov Kev Siv Kho Mob ntawm Hyperbaric Oxygen Therapy hauv Kev Kab Mob
Cov pov thawj tam sim no txhawb nqa kev siv HBOT, ob qho tib si ua kev kho mob ib leeg thiab kev kho mob ntxiv, muab cov txiaj ntsig zoo rau cov neeg mob uas muaj kab mob. Thaum lub sijhawm HBOT, cov ntshav oxygen siab tuaj yeem nce mus txog 2000 mmHg, thiab qhov tshwm sim ntawm cov pa oxygen-cov ntaub so ntswg siab tuaj yeem ua rau cov ntaub so ntswg oxygen ntau ntxiv mus txog 500 mmHg. Cov teebmeem no muaj txiaj ntsig zoo rau kev txhawb nqa kev kho cov lus teb inflammatory thiab microcirculatory disruptions pom hauv cov chaw ischemic, nrog rau kev tswj hwm compartment syndrome.
HBOT kuj tseem tuaj yeem cuam tshuam rau cov mob uas nyob ntawm lub cev tiv thaiv kab mob. Kev tshawb fawb qhia tau hais tias HBOT tuaj yeem tiv thaiv cov kab mob autoimmune thiab cov lus teb tiv thaiv kab mob uas ua rau muaj antigen, pab tswj kev kam rau graft los ntawm kev txo cov kev ncig ntawm cov lymphocytes thiab leukocytes thaum hloov kho cov lus teb tiv thaiv kab mob. Tsis tas li ntawd, HBOTtxhawb kev kho mobhauv cov qhov txhab ntawm daim tawv nqaij uas mob ntev los ntawm kev txhawb nqa angiogenesis, uas yog ib qho txheej txheem tseem ceeb rau kev kho kom zoo dua. Kev kho mob no kuj txhawb kom muaj collagen matrix, uas yog ib theem tseem ceeb hauv kev kho qhov txhab.
Yuav tsum tau ua tib zoo saib xyuas qee yam kab mob, tshwj xeeb yog cov kab mob tob thiab nyuaj kho xws li necrotizing fasciitis, osteomyelitis, kab mob nqaij mos ntev, thiab infectious endocarditis. Ib qho ntawm cov kev siv kho mob feem ntau ntawm HBOT yog rau cov kab mob nqaij mos thiab osteomyelitis uas cuam tshuam nrog cov pa oxygen tsawg uas feem ntau tshwm sim los ntawm cov kab mob anaerobic lossis cov kab mob tiv taus.
1. Kab mob ko taw uas mob ntshav qab zib
Kab mob ntshav qab zib ko tawCov qhov txhab yog ib qho teeb meem uas tshwm sim ntau ntawm cov neeg mob ntshav qab zib, cuam tshuam txog li 25% ntawm cov pej xeem no. Cov kab mob feem ntau tshwm sim hauv cov qhov txhab no (uas yog 40% -80% ntawm cov neeg mob) thiab ua rau muaj kev mob nkeeg thiab kev tuag ntau ntxiv. Cov kab mob ntshav qab zib ko taw (DFIs) feem ntau muaj cov kab mob polymicrobial nrog ntau yam kab mob anaerobic bacterial pathogens pom. Ntau yam tseem ceeb, suav nrog cov teeb meem fibroblast ua haujlwm, teeb meem tsim collagen, cov txheej txheem tiv thaiv kab mob, thiab phagocyte ua haujlwm, tuaj yeem cuam tshuam cov qhov txhab kho rau cov neeg mob ntshav qab zib. Ntau txoj kev tshawb fawb tau txheeb xyuas cov tawv nqaij tsis muaj oxygenation ua ib qho kev pheej hmoo loj rau kev txiav tawm ntsig txog DFIs.
Ua ib qho ntawm cov kev xaiv tam sim no rau kev kho mob DFI, HBOT tau tshaj tawm tias ua rau cov kab mob ntawm ko taw zoo dua qub, tom qab ntawd txo qhov xav tau kev txiav ceg thiab kev phais mob nyuaj. Nws tsis tsuas yog txo qhov xav tau cov txheej txheem siv nyiaj ntau, xws li kev phais mob thiab kev txiav tawv nqaij, tab sis kuj tseem muaj cov nqi qis dua thiab cov kev phiv tsawg dua piv rau kev phais mob. Ib txoj kev tshawb fawb los ntawm Chen et al. tau qhia tias ntau tshaj 10 zaug ntawm HBOT ua rau muaj kev txhim kho 78.3% hauv cov neeg mob ntshav qab zib.
2. Kev kis kab mob ntawm cov nqaij mos uas ua rau cov nqaij mos lwj
Cov kab mob nqaij mos uas ua rau cov kab mob necrotizing (NSTIs) feem ntau yog cov kab mob polymicrobial, feem ntau yog los ntawm kev sib xyaw ua ke ntawm cov kab mob aerobic thiab anaerobic thiab feem ntau yog txuam nrog kev tsim cov pa roj. Txawm hais tias NSTIs tsis tshua muaj, lawv muaj tus nqi tuag ntau vim lawv txoj kev loj hlob sai. Kev kuaj mob thiab kev kho mob raws sijhawm thiab tsim nyog yog qhov tseem ceeb rau kev ua tiav cov txiaj ntsig zoo, thiab HBOT tau raug pom zoo ua ib txoj hauv kev ntxiv rau kev tswj hwm NSTIs. Txawm hais tias tseem muaj kev sib cav txog kev siv HBOT hauv NSTIs vim tsis muaj kev tshawb fawb tswj hwm yav tom ntej,Cov pov thawj qhia tias nws yuav muaj feem cuam tshuam nrog kev txhim kho cov nqi ciaj sia thiab kev khaws cia cov kab mob hauv cov neeg mob NSTIIb txoj kev tshawb fawb rov qab qhia tau tias muaj kev txo qis ntawm cov neeg mob NSTI uas tau txais HBOT.
1.3 Kev kis kab mob ntawm qhov chaw phais
Cov kab mob SSIs muaj peev xwm muab faib ua pawg raws li qhov chaw ntawm tus kab mob thiab tuaj yeem tshwm sim los ntawm ntau yam kab mob, suav nrog cov kab mob aerobic thiab anaerobic. Txawm hais tias muaj kev nce qib hauv kev tswj kev kis kab mob, xws li cov txheej txheem tua kab mob, kev siv cov tshuaj tua kab mob prophylactic, thiab kev txhim kho hauv kev phais, SSIs tseem yog ib qho teeb meem uas nyob mus ib txhis.
Muaj ib qho kev tshuaj xyuas tseem ceeb tau tshawb nrhiav qhov ua tau zoo ntawm HBOT hauv kev tiv thaiv SSIs tob hauv kev phais mob neuromuscular scoliosis. HBOT ua ntej phais yuav txo qhov tshwm sim ntawm SSIs thiab pab kho qhov txhab. Kev kho mob tsis-invasive no tsim ib puag ncig uas cov pa oxygen hauv cov nqaij mob siab, uas tau cuam tshuam nrog kev ua haujlwm tua oxidative tawm tsam cov kab mob. Tsis tas li ntawd, nws hais txog cov ntshav thiab cov pa oxygen qis uas pab txhawb rau kev loj hlob ntawm SSIs. Dhau li ntawm lwm cov tswv yim tswj kev kis kab mob, HBOT tau pom zoo tshwj xeeb tshaj yog rau kev phais mob huv si xws li cov txheej txheem colorectal.
1.4 Kub hnyiab
Kev kub hnyiab yog kev raug mob los ntawm cua sov heev, hluav taws xob, tshuaj lom neeg, lossis kev tawm hluav taws xob thiab tuaj yeem ua rau muaj kev mob nkeeg thiab kev tuag ntau. HBOT muaj txiaj ntsig zoo rau kev kho mob kub hnyiab los ntawm kev ua kom cov pa oxygen ntau ntxiv hauv cov nqaij puas tsuaj. Thaum kev tshawb fawb txog tsiaj thiab kev kho mob muaj cov txiaj ntsig sib xyaw txogKev siv HBOT hauv kev kho mob kub hnyiab zoo, ib txoj kev tshawb fawb uas muaj 125 tus neeg mob kub hnyiab tau qhia tias HBOT tsis muaj qhov cuam tshuam loj rau tus nqi tuag lossis tus naj npawb ntawm kev phais tab sis tau txo lub sijhawm kho mob nruab nrab (19.7 hnub piv rau 43.8 hnub). Kev koom ua ke HBOT nrog kev tswj hwm kub hnyiab tag nrho tuaj yeem tswj tau sepsis hauv cov neeg mob kub hnyiab, ua rau lub sijhawm kho mob luv dua thiab txo qhov xav tau dej. Txawm li cas los xij, yuav tsum muaj kev tshawb fawb ntxiv kom paub meej tias HBOT lub luag haujlwm hauv kev tswj hwm kub hnyiab loj.
1.5 Mob pob txha
Kab mob Osteomyelitis yog ib qho kev kis kab mob ntawm pob txha lossis pob txha pob txha uas feem ntau tshwm sim los ntawm cov kab mob bacterial. Kev kho mob osteomyelitis tuaj yeem nyuaj vim tias cov ntshav tsis txaus rau pob txha thiab cov tshuaj tua kab mob nkag mus rau hauv pob txha tsawg. Kab mob osteomyelitis ntev yog tus yam ntxwv los ntawm cov kab mob uas nyob ntev, o me ntsis, thiab cov nqaij pob txha necrotic. Kab mob osteomyelitis uas tsis kho tau yog hais txog cov kab mob pob txha ntev uas txuas ntxiv lossis rov tshwm sim txawm tias kho tau zoo.
HBOT tau pom tias ua rau cov pa oxygen hauv cov pob txha uas muaj kab mob zoo dua qub. Muaj ntau cov kev tshawb fawb thiab cov kev tshawb fawb qhia tias HBOT ua rau cov neeg mob osteomyelitis zoo dua. Nws zoo li ua haujlwm los ntawm ntau yam txheej txheem, suav nrog kev txhawb nqa kev ua haujlwm ntawm lub cev, tiv thaiv cov kab mob bacterial, txhim kho cov tshuaj tua kab mob, txo qhov mob, thiab txhawb kev kho mob.cov txheej txheem. Tom qab HBOT, 60% txog 85% ntawm cov neeg mob uas muaj mob osteomyelitis ntev, tsis kho tau qhia cov cim qhia tias kev kis kab mob tsis zoo.
1.6 Kab mob fungal
Thoob plaws ntiaj teb, muaj ntau tshaj peb lab tus tib neeg raug kev txom nyem los ntawm kev mob fungal ntev lossis kev kis tus kab mob, ua rau muaj ntau tshaj 600,000 tus neeg tuag txhua xyoo. Cov txiaj ntsig kev kho mob rau cov kab mob fungal feem ntau raug cuam tshuam vim muaj cov yam ntxwv xws li kev hloov pauv ntawm lub cev tiv thaiv kab mob, cov kab mob hauv qab, thiab cov yam ntxwv ntawm cov kab mob pathogen. HBOT tab tom dhau los ua ib qho kev xaiv kho mob zoo rau cov kab mob fungal hnyav vim nws muaj kev nyab xeeb thiab tsis kis tus kab mob. Cov kev tshawb fawb qhia tau tias HBOT tuaj yeem ua tau zoo tiv thaiv cov kab mob fungal xws li Aspergillus thiab Mycobacterium tuberculosis.
HBOT txhawb nqa cov teebmeem antifungal los ntawm kev txwv tsis pub tsim cov biofilm ntawm Aspergillus, nrog rau kev ua haujlwm zoo dua hauv cov kab mob uas tsis muaj superoxide dismutase (SOD) genes. Cov xwm txheej hypoxic thaum muaj kab mob fungal ua rau muaj kev cov nyom rau kev xa tshuaj antifungal, ua rau cov pa oxygen ntau ntxiv los ntawm HBOT yog qhov kev cuam tshuam zoo, txawm hais tias kev tshawb fawb ntxiv yog qhov tsim nyog.
Cov Khoom Siv Antimicrobial ntawm HBOT
Qhov chaw muaj pa phem heev uas HBOT tsim tawm ua rau muaj kev hloov pauv ntawm lub cev thiab cov tshuaj lom neeg uas ua rau muaj cov tshuaj tua kab mob, ua rau nws yog ib qho kev kho mob zoo rau kev kis kab mob. HBOT ua rau pom cov txiaj ntsig zoo kawg nkaus tiv thaiv cov kab mob aerobic thiab feem ntau yog cov kab mob anaerobic los ntawm cov txheej txheem xws li kev ua haujlwm tua kab mob ncaj qha, kev txhim kho kev tiv thaiv kab mob, thiab cov teebmeem synergistic nrog cov neeg sawv cev antimicrobial tshwj xeeb.
2.1 Cov teebmeem tiv thaiv kab mob ncaj qha ntawm HBOT
Qhov cuam tshuam ncaj qha ntawm HBOT yog vim muaj cov tshuaj reactive oxygen species (ROS), uas suav nrog superoxide anions, hydrogen peroxide, hydroxyl radicals, thiab hydroxyl ions - tag nrho cov no tshwm sim thaum lub sijhawm cellular metabolism.
Qhov kev sib cuam tshuam ntawm O₂ thiab cov khoom sib txuas ntawm tes yog qhov tseem ceeb hauv kev nkag siab txog ROS tsim li cas hauv cov hlwb. Nyob rau hauv qee qhov xwm txheej hu ua kev ntxhov siab oxidative, qhov sib npaug ntawm ROS tsim thiab nws qhov kev puas tsuaj raug cuam tshuam, ua rau muaj cov qib siab ntawm ROS hauv cov hlwb. Kev tsim cov superoxide (O₂⁻) yog catalyzed los ntawm superoxide dismutase, uas tom qab ntawd hloov O₂⁻ mus rau hauv hydrogen peroxide (H₂O₂). Qhov kev hloov pauv no tau nthuav dav ntxiv los ntawm Fenton reaction, uas oxidizes Fe²⁺ los tsim cov hydroxyl radicals (·OH) thiab Fe³⁺, yog li pib qhov kev puas tsuaj redox ntawm ROS tsim thiab kev puas tsuaj ntawm tes.
Cov teeb meem lom ntawm ROS tsom mus rau cov khoom tseem ceeb ntawm lub cev xws li DNA, RNA, cov protein, thiab lipids. Qhov tseem ceeb, DNA yog lub hom phiaj tseem ceeb ntawm H₂O₂-mediated cytotoxicity, vim nws cuam tshuam cov qauv deoxyribose thiab ua puas rau cov khoom xyaw hauv paus. Kev puas tsuaj ntawm lub cev uas ROS ua rau nthuav dav mus rau cov qauv helix ntawm DNA, tej zaum yog los ntawm lipid peroxidation uas ROS ua rau. Qhov no qhia txog cov teeb meem tsis zoo ntawm cov qib ROS siab hauv cov kab ke hauv lub cev.
Kev Ua Haujlwm Tiv Thaiv Kab Mob ntawm ROS
ROS ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev loj hlob ntawm cov kab mob me me, raws li tau pom los ntawm HBOT-induced ROS tiam. Cov teebmeem lom ntawm ROS ncaj qha tsom mus rau cov khoom siv hauv lub cev xws li DNA, cov protein, thiab lipids. Cov concentration ntawm cov pa oxygen nquag tuaj yeem ua rau cov lipids puas tsuaj ncaj qha, ua rau lipid peroxidation. Cov txheej txheem no ua rau lub cell membranes tsis ruaj khov thiab, yog li ntawd, kev ua haujlwm ntawm cov membrane-associated receptors thiab proteins.
Ntxiv mus, cov protein, uas yog cov hom phiaj tseem ceeb ntawm ROS, raug hloov kho tshwj xeeb ntawm ntau yam amino acid residues xws li cysteine, methionine, tyrosine, phenylalanine, thiab tryptophan. Piv txwv li, HBOT tau pom tias ua rau muaj kev hloov pauv oxidative hauv ntau cov protein hauv E. coli, suav nrog elongation factor G thiab DnaK, yog li cuam tshuam rau lawv cov haujlwm cellular.
Txhim Kho Kev Tiv Thaiv Kab Mob Los Ntawm HBOT
Cov khoom tiv thaiv kev o ntawm HBOTtau raug sau tseg, ua pov thawj tias tseem ceeb rau kev txo cov nqaij puas tsuaj thiab tiv thaiv kev kis tus kab mob. HBOT cuam tshuam rau kev qhia tawm ntawm cytokines thiab lwm yam kev tswj hwm kev mob, cuam tshuam rau kev teb tiv thaiv kab mob. Ntau yam kev sim tau pom cov kev hloov pauv sib txawv hauv kev qhia tawm gene thiab cov protein tiam tom qab HBOT, uas yog upregulate lossis downregulate cov yam ntxwv loj hlob thiab cytokines.
Thaum lub sijhawm HBOT, cov O₂ ntau ntxiv ua rau muaj ntau yam kev teb ntawm lub cev, xws li kev txwv tsis pub tso cov tshuaj pro-inflammatory thiab txhawb kev tuag ntawm cov lymphocyte thiab neutrophil. Ua ke, cov haujlwm no ua rau lub cev tiv thaiv kab mob ua haujlwm zoo dua, yog li ua rau kev kho mob zoo dua.
Ntxiv mus, kev tshawb fawb qhia tias kev nce O₂ theem thaum lub sijhawm HBOT tuaj yeem txo qhov kev qhia tawm ntawm cov cytokines pro-inflammatory, suav nrog interferon-gamma (IFN-γ), interleukin-1 (IL-1), thiab interleukin-6 (IL-6). Cov kev hloov pauv no kuj suav nrog kev txo qis qhov piv ntawm CD4: CD8 T hlwb thiab modulating lwm cov receptors soluble, thaum kawg tsa interleukin-10 (IL-10) theem, uas yog qhov tseem ceeb rau kev tiv thaiv kev o thiab txhawb kev kho mob.
Cov kev ua haujlwm tiv thaiv kab mob ntawm HBOT yog intertwined nrog cov txheej txheem biological nyuaj. Ob qho tib si superoxide thiab siab siab tau tshaj tawm tias tsis sib xws txhawb nqa HBOT-induced antibacterial kev ua ub no thiab neutrophil apoptosis. Tom qab HBOT, qhov nce siab hauv cov pa oxygen ua rau cov peev xwm bactericidal ntawm neutrophils, ib qho tseem ceeb ntawm kev tiv thaiv kab mob. Ntxiv mus, HBOT suppresses neutrophil adhesion, uas yog mediated los ntawm kev sib cuam tshuam ntawm β-integrins ntawm neutrophils nrog intercellular adhesion molecules (ICAM) ntawm endothelial hlwb. HBOT inhibits qhov kev ua haujlwm ntawm neutrophil β-2 integrin (Mac-1, CD11b / CD18) los ntawm nitric oxide (NO) -mediated txheej txheem, pab txhawb rau kev tsiv teb tsaws chaw ntawm neutrophils mus rau qhov chaw ntawm kev kis kab mob.
Qhov kev hloov pauv ntawm cov cytoskeleton kom raug yog qhov tsim nyog rau neutrophils kom ua tau zoo phagocytize cov kab mob. S-nitrosylation ntawm actin tau pom tias txhawb nqa actin polymerization, tej zaum yuav pab txhawb kev ua haujlwm phagocytic ntawm neutrophils tom qab HBOT ua ntej kev kho mob. Ntxiv mus, HBOT txhawb nqa apoptosis hauv tib neeg T cell kab los ntawm mitochondrial txoj kev, nrog rau kev tuag sai sai tom qab HBOT tau tshaj tawm. Kev thaiv caspase-9—tsis cuam tshuam rau caspase-8—tau ua pov thawj cov teebmeem immunomodulatory ntawm HBOT.
Cov Teebmeem Synergistic ntawm HBOT nrog Antimicrobial Agents
Hauv kev siv kho mob, HBOT feem ntau siv nrog rau cov tshuaj tua kab mob kom tiv thaiv kev kis kab mob kom zoo. Lub xeev hyperoxic ua tiav thaum lub sijhawm HBOT tuaj yeem cuam tshuam rau qhov ua tau zoo ntawm qee cov tshuaj tua kab mob. Kev tshawb fawb qhia tias cov tshuaj tua kab mob tshwj xeeb, xws li β-lactams, fluoroquinolones, thiab aminoglycosides, tsis yog tsuas yog ua los ntawm cov txheej txheem tseem ceeb xwb tab sis kuj vam khom ib feem ntawm cov kab mob aerobic metabolism. Yog li ntawd, qhov muaj oxygen thiab cov yam ntxwv metabolic ntawm cov kab mob yog qhov tseem ceeb thaum soj ntsuam cov txiaj ntsig kho mob ntawm cov tshuaj tua kab mob.
Muaj pov thawj tseem ceeb qhia tau tias cov pa oxygen tsawg tuaj yeem ua rau Pseudomonas aeruginosa tiv taus piperacillin/tazobactam thiab tias qhov chaw oxygen tsawg kuj ua rau Enterobacter cloacae tiv taus azithromycin ntau ntxiv. Ntawm qhov tod tes, qee yam mob hypoxic yuav ua rau cov kab mob rhiab heev rau cov tshuaj tua kab mob tetracycline. HBOT ua haujlwm ua ib txoj kev kho mob ntxiv los ntawm kev ua kom cov metabolism aerobic thiab rov ua kom cov ntaub so ntswg hypoxic muaj zog, tom qab ntawd ua rau cov kab mob rhiab heev rau cov tshuaj tua kab mob.
Hauv kev tshawb fawb ua ntej, kev sib xyaw ua ke ntawm HBOT—muab ob zaug ib hnub rau 8 teev ntawm 280 kPa—ua ke nrog tobramycin (20 mg/kg/hnub) txo cov kab mob hauv Staphylococcus aureus infectious endocarditis. Qhov no qhia tau tias HBOT muaj peev xwm ua kev kho mob pab. Kev tshawb fawb ntxiv tau qhia tias nyob rau hauv 37°C thiab 3 ATA siab rau 5 teev, HBOT tau txhim kho cov teebmeem ntawm imipenem tawm tsam macrophage-infected Pseudomonas aeruginosa. Tsis tas li ntawd, kev sib xyaw ua ke ntawm HBOT nrog cephazolin tau pom tias muaj txiaj ntsig zoo dua hauv kev kho Staphylococcus aureus osteomyelitis hauv cov qauv tsiaj piv rau cephazolin ib leeg.
HBOT kuj tseem ua rau ciprofloxacin ua haujlwm tua kab mob ntau ntxiv rau Pseudomonas aeruginosa biofilms, tshwj xeeb tshaj yog tom qab 90 feeb ntawm kev raug tshuaj. Qhov kev txhim kho no yog vim muaj kev tsim cov endogenous reactive oxygen species (ROS) thiab qhia txog kev rhiab heev hauv cov peroxidase-defective mutants.
Hauv cov qauv ntawm cov kab mob pleuritis uas tshwm sim los ntawm methicillin-resistant Staphylococcus aureus (MRSA), qhov kev sib koom tes ntawm vancomycin, teicoplanin, thiab linezolid nrog HBOT tau qhia txog kev ua haujlwm zoo dua tiv thaiv MRSA. Metronidazole, ib qho tshuaj tua kab mob uas siv dav hauv kev kho mob hnyav anaerobic thiab polymicrobial xws li cov kab mob ntshav qab zib ko taw (DFIs) thiab cov kab mob phais (SSIs), tau pom tias muaj txiaj ntsig zoo dua rau kev tua kab mob hauv qab cov mob anaerobic. Cov kev tshawb fawb yav tom ntej yuav tsum tshawb nrhiav cov teebmeem synergistic antibacterial ntawm HBOT ua ke nrog metronidazole hauv ob qho tib si hauv vivo thiab hauv vitro.
Kev Ua Haujlwm Zoo ntawm HBOT rau Cov Kab Mob Tiv Thaiv Kab Mob
Nrog rau kev hloov pauv thiab kev kis ntawm cov kab mob uas tiv taus, cov tshuaj tua kab mob ib txwm muaj feem ntau poob lawv lub zog dhau sijhawm. Ntxiv mus, HBOT tej zaum yuav tseem ceeb hauv kev kho thiab tiv thaiv kev kis kab mob los ntawm cov kab mob uas tiv taus ntau yam tshuaj, ua haujlwm ua lub tswv yim tseem ceeb thaum kev kho mob tshuaj tua kab mob tsis ua haujlwm. Ntau txoj kev tshawb fawb tau tshaj tawm txog cov teebmeem tseem ceeb ntawm HBOT rau cov kab mob uas tiv taus kev kho mob. Piv txwv li, kev sib tham HBOT 90 feeb ntawm 2 ATM tau txo qhov kev loj hlob ntawm MRSA. Ntxiv mus, hauv cov qauv piv, HBOT tau txhim kho cov teebmeem tua kab mob ntawm ntau yam tshuaj tua kab mob tawm tsam MRSA. Cov ntawv ceeb toom tau lees paub tias HBOT muaj txiaj ntsig zoo hauv kev kho mob osteomyelitis los ntawm OXA-48-tsim Klebsiella pneumoniae yam tsis tas yuav muaj cov tshuaj tua kab mob ntxiv.
Hauv kev xaus lus, kev kho mob hyperbaric oxygen yog ib txoj hauv kev ntau yam los tswj kev kis kab mob, txhim kho kev tiv thaiv kab mob thaum tseem ua kom cov tshuaj tua kab mob uas twb muaj lawm ua haujlwm tau zoo dua. Nrog kev tshawb fawb thiab kev txhim kho dav dav, nws muaj peev xwm txo cov teebmeem ntawm kev tiv thaiv tshuaj tua kab mob, muab kev cia siab rau kev sib ntaus sib tua tiv thaiv kab mob.
Lub sijhawm tshaj tawm: Lub Ob Hlis-28-2025