Kab mob stroke, yog ib yam mob loj heev uas ua rau cov ntshav tsis txaus rau lub hlwb vim yog mob hemorrhagic lossis ischemic, yog qhov thib ob ua rau neeg tuag thoob ntiaj teb thiab thib peb ua rau neeg tsis taus. Ob hom kab mob stroke tseem ceeb yog ischemic stroke (muaj txog 68%) thiab hemorrhagic stroke (32%). Txawm hais tias lawv muaj cov kab mob sib txawv thaum pib, ob qho tib si thaum kawg ua rau cov ntshav tsis txaus thiab tom qab ntawd cerebral ischemia thaum lub sijhawm subacute thiab mob ntev.
Mob stroke ischemic
Mob stroke Ischemic (AIS) yog cim los ntawm kev txhaws ntawm cov hlab ntsha tam sim ntawd, ua rau muaj kev puas tsuaj rau thaj chaw raug mob. Hauv theem mob hnyav, qhov chaw hypoxic thawj zaug no ua rau muaj kev lom zem ntawm excitotoxicity, kev ntxhov siab oxidative, thiab kev ua haujlwm ntawm microglia, ua rau muaj kev tuag ntawm cov hlab ntsha. Thaum lub sijhawm subacute, kev tso tawm ntawm cytokines, chemokines, thiab matrix metalloproteinases (MMPs) tuaj yeem ua rau neuroinflammation. Qhov tseem ceeb, cov qib siab ntawm MMPs ua rau muaj kev nkag mus ntawm cov ntshav-lub hlwb barrier (BBB), tso cai rau leukocyte migration mus rau hauv thaj chaw infarcted, ua rau muaj kev ua haujlwm inflammatory.
Cov Kev Kho Mob Tam Sim No Rau Ischemic Stroke
Cov kev kho mob tseem ceeb rau AIS suav nrog thrombolysis thiab thrombectomy. Kev thrombolysis hauv cov hlab ntsha tuaj yeem pab tau cov neeg mob hauv 4.5 teev, qhov twg kev kho mob thaum ntxov txhais tau tias muaj txiaj ntsig zoo dua. Piv rau thrombolysis, kev siv tshuab thrombectomy muaj lub sijhawm kho mob dav dua. Tsis tas li ntawd, kev kho mob uas tsis siv tshuaj, tsis yog kev phais xws likev kho mob oxygen, acupuncture, thiab electrical stimulation tau txais kev txhawb nqa raws li kev kho mob ntxiv rau cov txheej txheem ib txwm muaj.
Cov Ntsiab Lus Tseem Ceeb ntawm Hyperbaric Oxygen Therapy (HBOT)
Nyob rau ntawm qhov siab ntawm dej hiav txwv (1 ATA = 101.3 kPa), cov huab cua uas peb ua pa muaj kwv yees li 21% oxygen. Nyob rau hauv cov xwm txheej physiological, qhov feem pua ntawm cov pa oxygen yaj hauv plasma yog tsawg heev, tsuas yog li 0.29 mL (0.3%) ib 100 mL ntawm cov ntshav. Nyob rau hauv cov xwm txheej hyperbaric, kev nqus pa 100% oxygen ua rau cov pa oxygen yaj hauv plasma ntau ntxiv - txog li 3.26% ntawm 1.5 ATA thiab 5.6% ntawm 2.5 ATA. Yog li ntawd, HBOT lub hom phiaj yog txhim kho qhov feem ntawm cov pa oxygen yaj no, kom zoo.ua rau cov pa oxygen ntau ntxiv rau hauv cov nqaij hauv thaj chaw ischemic. Thaum muaj kev nyuaj siab ntau dua, cov pa oxygen kis tau yooj yim dua rau hauv cov nqaij hypoxic, ncav cuag qhov deb ntawm kev sib kis ntev dua piv rau qhov siab ntawm huab cua ib txwm muaj.
Txog niaj hnub no, HBOT tau pom kev siv dav dav rau ob qho tib si ischemic thiab hemorrhagic strokes. Kev tshawb fawb qhia tau tias HBOT muab cov teebmeem neuroprotective los ntawm ntau yam molecular, biochemical, thiab hemodynamic mechanisms, suav nrog:
1. Ua kom cov pa oxygen hauv cov hlab ntsha nce ntxiv, ua kom cov pa oxygen xa mus rau cov ntaub so ntswg ntawm lub hlwb zoo dua.
2. Kev ruaj khov ntawm BBB, txo qhov o ntawm lub hlwb.
3. Kev txhim kho ntawm lub hlwbkev ncig ntshav me me, txhim kho lub hlwb metabolism thiab lub zog tsim thaum tswj hwm cellular ion homeostasis.
4. Kev tswj cov ntshav ntws hauv lub hlwb kom txo tau qhov siab hauv lub hlwb thiab txo qhov o ntawm lub hlwb.
5. Kev txo qis ntawm kev mob hlwb tom qab mob stroke.
6. Kev tiv thaiv apoptosis thiab necrosistom qab mob stroke.
7. Kev txo qhov kev ntxhov siab oxidative thiab kev tiv thaiv kev raug mob reperfusion, tseem ceeb hauv kev mob stroke pathophysiology.
8. Kev tshawb fawb qhia tias HBOT tuaj yeem txo qhov vasospasm tom qab aneurysmal subarachnoid hemorrhage (SAH).
9. Cov pov thawj kuj txhawb nqa qhov txiaj ntsig ntawm HBOT hauv kev txhawb nqa neurogenesis thiab angiogenesis.
Xaus lus
Kev kho mob siv pa oxygen ntau dhau yog ib txoj kev kho mob zoo rau cov neeg mob stroke. Thaum peb tseem tab tom kawm txog qhov nyuaj ntawm kev rov zoo los ntawm stroke, kev tshawb nrhiav ntxiv yuav tseem ceeb heev rau peb kom nkag siab txog lub sijhawm, kev siv tshuaj, thiab cov txheej txheem ntawm HBOT.
Hauv kev xaus lus, thaum peb tshawb nrhiav cov txiaj ntsig ntawm kev kho mob hyperbaric oxygen rau mob stroke, nws pom tseeb tias kev siv txoj kev kho mob no muaj peev xwm hloov pauv txoj hauv kev uas peb tswj hwm ischemic strokes, xa kev cia siab rau cov neeg cuam tshuam los ntawm qhov mob hloov pauv lub neej no.
Yog tias koj xav tshawb nrhiav kev kho mob oxygen hyperbaric ua kev kho mob rau kev rov zoo los ntawm mob stroke, peb caw koj tuaj xyuas peb lub vev xaib kom paub ntau ntxiv txog peb cov chav oxygen hyperbaric siab heev. Nrog ntau yam qauv tsim rau kev siv hauv tsev thiab kev ua haujlwm, MACY-PAN muab cov kev daws teeb meem uas xa cov kev kho mob oxygen zoo, tsom mus rau koj txoj kev noj qab haus huv thiab kev rov zoo.
Tshawb nrhiav peb cov khoom thiab lawv tuaj yeem txhim kho koj txoj kev noj qab haus huv li cas ntawmwww.hbotmacypan.com.
Lub sijhawm tshaj tawm: Lub Ob Hlis-18-2025